Mounjaro (generic name: tirzepatide) is an injectable prescription medicine that is used to treat adults with type 2 diabetes. It is prescribed along with diet and exercise to improve control of blood sugar levels. Mounjaro is widely used thanks to its efficacy and safety as a single therapy or with other diabetes medicines. Tirzepatide (GIP/GLP-1RA) is a single molecule combining glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1RA). It activates the secretion of GIP and GLP-1 receptors from the intestines on ingestion of glucose or nutrients, which in turn stimulates insulin secretion from pancreatic β cells. It also is active in regions of the brain that regulate food intake. Tirzepatide slows down the emptying of the stomach after eating, leaving people feeling full for longer and suppressing appetite. Mounjaro is not for use in people with type 1 diabetes. While there is no cure for diabetes, it was found in studies of Mounjaro that after 52 weeks, when administered both with or without other diabetes medications, 75% to 90% of patients with an average starting HbA1C of 7.9% to 8.6% reached an HbA1C of less than 7%. Mounjaro is also effective to help with body weight reduction and was approved by the FDA for this putpose in November 2023.  In studies, weight loss in adults ranged from 12 lb (5 kg) to 25 lb (10 kg). The results in studies where candidates received tirzepatide surpass trials of other GLP-1 agonists. Mounjaro can be prescribed for patients classified as overweight (BMI of 27 – 29.9 with at least one weight-related comorbid condition, such as dyslipidemia, hypertension, obstructive sleep apnea, or cardiovascular disease) or obese (BMI greater than 30)
Dosage
Mounjaro comes in single-dose vials with syringes for subcutaneous injection. It should be administered once each week on the same day of the week and at approximately the same time of day. It must injected in rotation in either the abdomen, thigh, or upper arm by choosing a different site each week. If a dose is missed, it can be made up for within three days, but beyond that, the dose must be skipped and the routine dose taken on the due date. Do not take two doses of Mounjaro within 72 hours of each other and if it is necessary to change the day, make sure there are at least 72 hours in between doses. If taking insulin and Mounjaro simultaneously, do not inject them close together in the same area.  Carefully read the information and follow instructions on the manufacturer Eli Lilly and Company’s Product Insert leaflet that comes with the medication to ensure safe usage. Watch a step-by-step video on how to use Mounjaro. We cannot be held liable for any harm caused by incorrect usage.
Some of the most common side effects of Mounjaro are:
- Nausea
- Diarrhea
- Decreased appetite
- Vomiting
- Constipation
- Indigestion
- Stomach pain.
If these persist or worsen, consult with a healthcare provider.
Most nausea, vomiting, and diarrhea events occurred while the dose of Mounjaro was being increased and this decreased over time.
Please note that not all possible side effects can be listed. If any of these or other unexpected side effects are experienced, seek medical attention promptly.
Cautions
For people who have kidney problems, side effects like diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important to drink fluids to help reduce any chance of dehydration.
Gallbladder problems have been reported by some people using Mounjaro. Tell a healthcare provider right away if symptoms of gallbladder problems appear, which may include pain in the upper abdomen, fever, yellowing of skin or eyes (jaundice), and clay-colored stools.
Mounjaro may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.
- Do not use Mounjaro if you or any member of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
- Do not use Mounjaro if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
- Do not use Mounjaro if you are allergic to it or any of the ingredients in Mounjaro.
Mounjaro may cause serious side effects, including:
- Inflammation of the pancreas (pancreatitis). Stop using Mounjaro and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
- Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Mounjaro with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, or mood changes, hunger, weakness and feeling jittery.
- Serious allergic reactions. Stop using Mounjaro and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, and very rapid heartbeat.
- Changes in vision. Tell your healthcare provider if you have changes in vision during treatment with Mounjaro.
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